Endocrine Abstracts

Pro-opiomelanocortin (POMC) deficiency in mice and humans results in a syndrome of severe obesity, hyperphagia and adrenal insufficiency. We have used mice heterozygous for a null mutation in the Pomc allele (Pomc+/-) to determine if POMC haploinsufficiency results in disordered energy homeostasis or adrenal hypofunction.When fed standard lab diet (SLD, 4.5% fat) Pomc+/-were similar in weight to wild type (WT) mice thr...